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Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels
BACKGROUND: TRPM8 is a non-selective cation channel that belongs to the melastatin subfamily of the transient receptor potential (TRP) ion channels. TRPM8 is activated by voltage, cold and cooling compounds such as menthol. Despite its essential role for cold temperature sensing in mammals, the phar...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778643/ https://ncbi.nlm.nih.gov/pubmed/19886999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-62 |
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