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Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels

BACKGROUND: TRPM8 is a non-selective cation channel that belongs to the melastatin subfamily of the transient receptor potential (TRP) ion channels. TRPM8 is activated by voltage, cold and cooling compounds such as menthol. Despite its essential role for cold temperature sensing in mammals, the phar...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Malkia, Annika, Pertusa, María, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Viana, Félix
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778643/
https://ncbi.nlm.nih.gov/pubmed/19886999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-62
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