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Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors

TRPM8, a member of the melastatin subfamily of transient receptor potential (TRP) cation channels, is activated by voltage, low temperatures and cooling compounds. These properties and its restricted expression to small sensory neurons have made it the ion channel with the most advocated role in col...

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Autors principals: Mälkiä, Annika, Madrid, Rodolfo, Meseguer, Victor, de la Peña, Elvira, Valero, María, Belmonte, Carlos, Viana, Félix
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075222/
https://ncbi.nlm.nih.gov/pubmed/17317754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.123059
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