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Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-terminal Domain

TRPM8, a nonselective cation channel activated by cold, voltage, and cooling compounds such as menthol, is the principal molecular detector of cold temperatures in primary sensory neurons of the somatosensory system. The N-terminal domain of TRPM8 consists of 693 amino acids, but little is known abo...

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Main Authors: Pertusa, María, González, Alejandro, Hardy, Paulina, Madrid, Rodolfo, Viana, Félix
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139203/
https://ncbi.nlm.nih.gov/pubmed/24917670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565994
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