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Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity
The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripheral neuropathies. Moreover, these channels are aberrantly expressed in different cancers, an...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7447632/ https://ncbi.nlm.nih.gov/pubmed/32843690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70691-x |
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