Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripheral neuropathies. Moreover, these channels are aberrantly expressed in different cancers, an...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bonache, M.Ángeles, Martín-Escura, Cristina, de la Torre Martínez, Roberto, Medina, Alicia, González-Rodríguez, Sara, Francesch, Andrés, Cuevas, Carmen, Roa, Ana María, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, González-Muñiz, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7447632/
https://ncbi.nlm.nih.gov/pubmed/32843690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70691-x
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