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Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists
The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersensitivity characteristic of some types of neuropathic pain, as well as in cancer. Consequentl...
में बचाया:
| में प्रकाशित: | Sci Rep |
|---|---|
| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group UK
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589751/ https://ncbi.nlm.nih.gov/pubmed/28883526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10913-x |
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