Initial Testing of VS-4718, a novel inhibitor of Focal Adhesion Kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program

VS-4718 was tested against the PPTP’s in vitro cell line panel and showed a median relative IC(50) of 1.22 µM. VS-4718 was tested in vivo against the PPTP xenograft models using a dose of 50 mg/kg administered by the oral route twice daily for 21 days. VS-4718 induced significant differences in EFS...

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Publicado no:Pediatr Blood Cancer
Main Authors: Kurmasheva, Raushan T., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Maris, John M., Lock, Richard B., Carol, Hernan, Kang, Jiarong Min, Reynolds, C. Patrick, Wu, Jianrong, Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578428/
https://ncbi.nlm.nih.gov/pubmed/27786412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.26304
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