Initial Testing of VS-4718, a novel inhibitor of Focal Adhesion Kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program

VS-4718 was tested against the PPTP’s in vitro cell line panel and showed a median relative IC(50) of 1.22 µM. VS-4718 was tested in vivo against the PPTP xenograft models using a dose of 50 mg/kg administered by the oral route twice daily for 21 days. VS-4718 induced significant differences in EFS...

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Veröffentlicht in:Pediatr Blood Cancer
Hauptverfasser: Kurmasheva, Raushan T., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Maris, John M., Lock, Richard B., Carol, Hernan, Kang, Jiarong Min, Reynolds, C. Patrick, Wu, Jianrong, Houghton, Peter J., Smith, Malcolm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578428/
https://ncbi.nlm.nih.gov/pubmed/27786412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.26304
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