Synthesis and characterization in monkey of [(11)C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors

PURPOSE: [(18)F]SP203 (3-fluoro−5-(2− (2-([(18)F]fluoromethyl)-thiazol−4-yl)ethynyl)benzonitrile) is an effective high-affinity and selective radioligand for imaging metabotropic 5 receptors (mGluR5) in human brain with PET. To provide a radioligand that may be used for more than one scanning sessio...

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Gepubliceerd in:Eur J Nucl Med Mol Imaging
Hoofdauteurs: Siméon, Fabrice G., Liow, Jeih-San, Zhang, Yi, Hong, Jinsoo, Gladding, Robert L., Zoghbi, Sami S., Innis, Robert B., Pike, Victor W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577640/
https://ncbi.nlm.nih.gov/pubmed/22885775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-012-2205-x
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