Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix

The ETS transcriptional repressor ETV6 (or TEL) is autoinhibited by an α-helix that sterically blocks its DNA-binding ETS domain. The inhibitory helix is marginally stable and unfolds when ETV6 binds to either specific or non-specific DNA. Using NMR spectroscopy, we show that folding of the inhibito...

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Vydáno v:J Mol Biol
Hlavní autoři: De, Soumya, Okon, Mark, Graves, Barbara J., McIntosh, Lawrence P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575937/
https://ncbi.nlm.nih.gov/pubmed/26920109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.02.020
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