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Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix
The ETS transcriptional repressor ETV6 (or TEL) is autoinhibited by an α-helix that sterically blocks its DNA-binding ETS domain. The inhibitory helix is marginally stable and unfolds when ETV6 binds to either specific or non-specific DNA. Using NMR spectroscopy, we show that folding of the inhibito...
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| Publicat a: | J Mol Biol |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575937/ https://ncbi.nlm.nih.gov/pubmed/26920109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.02.020 |
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