Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma

BACKGROUND. Biomarkers can improve clinical trial efficiency, but designing and interpreting biomarker-driven trials require knowledge of relationships among biomarkers, clinical covariates, and endpoints. We investigated these relationships across genomic subgroups of glioblastoma (GBM) within our...

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Vydáno v:Neuro Oncol
Hlavní autoři: Tanguturi, Shyam K., Trippa, Lorenzo, Ramkissoon, Shakti H., Pelton, Kristine, Knoff, David, Sandak, David, Lindeman, Neal I., Ligon, Azra H., Beroukhim, Rameen, Parmigiani, Giovanni, Wen, Patrick Y., Ligon, Keith L., Alexander, Brian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570228/
https://ncbi.nlm.nih.gov/pubmed/28339723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now312
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