Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma

BACKGROUND: Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE) specific to XPO1 i...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Green, Adam L., Ramkissoon, Shakti H., McCauley, Dilara, Jones, Kristen, Perry, Jennifer A., Hsu, Jessie Hao-Ru, Ramkissoon, Lori A., Maire, Cecile L., Hubbell-Engler, Benjamin, Knoff, David S., Shacham, Sharon, Ligon, Keith L., Kung, Andrew L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482855/
https://ncbi.nlm.nih.gov/pubmed/25366336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou303
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