KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-ALL and AML

This study explored the anti-leukaemic efficacy of novel irreversible inhibitors of the major nuclear export receptor, chromosome region maintenance 1 (CRM1, also termed XPO1). We found that these novel CRM1 antagonists, termed SINE (Selective Inhibitors of Nuclear Export), induced rapid apoptosis a...

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Detaylı Bibliyografya
Asıl Yazarlar: Etchin, Julia, Sanda, Takaomi, Mansour, Marc R., Kentsis, Alex, Montero, Joan, Le, Bonnie T., Christie, Amanda L., McCauley, Dilara, Rodig, Scott J., Kauffman, Michael, Shacham, Sharon, Stone, Richard, Letai, Anthony, Kung, Andrew L., Look, A. Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980736/
https://ncbi.nlm.nih.gov/pubmed/23373539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12231
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