Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice

Currently available combination chemotherapy for acute myeloid leukemia (AML) often fails to result in long-term remissions, emphasizing the need for novel therapeutic strategies. We reasoned that targeted inhibition of a prominent nuclear exporter, XPO1/CRM1, could eradicate self-renewing leukemia-...

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Publicat a:Leukemia
Autors principals: Etchin, J, Montero, J, Berezovskaya, A, Le, BT, Kentsis, A, Christie, AL, Conway, AS, Chen, WC, Reed, C, Mansour, MR, Ng, CEL, Adamia, S, Rodig, SJ, Galinsky, IA, Stone, RM, Klebanov, B, Landesman, Y, Kauffman, M, Shacham, S, Kung, AL, Wang, JCY, Letai, A, Look, AT
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994896/
https://ncbi.nlm.nih.gov/pubmed/26202935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.194
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