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Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancers. In this study, we examined the therapeutic potential of selinexor...

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Τόπος έκδοσης:	Sci Rep
Κύριοι συγγραφείς:	Garg, Manoj, Kanojia, Deepika, Mayakonda, Anand, Ganesan, Trivadi S, Sadhanandhan, Bindhya, Suresh, Sidhanth, S., Sneha, Nagare, Rohit P., Said, Jonathan W., Doan, Ngan B., Ding, Ling-Wen, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Koeffler, H. Phillip
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group UK 2017
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5575339/ https://ncbi.nlm.nih.gov/pubmed/28852098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10325-x
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Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

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