Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancers. In this study, we examined the therapeutic potential of selinexor...

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Publicado no:Sci Rep
Main Authors: Garg, Manoj, Kanojia, Deepika, Mayakonda, Anand, Ganesan, Trivadi S, Sadhanandhan, Bindhya, Suresh, Sidhanth, S., Sneha, Nagare, Rohit P., Said, Jonathan W., Doan, Ngan B., Ding, Ling-Wen, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Koeffler, H. Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575339/
https://ncbi.nlm.nih.gov/pubmed/28852098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10325-x
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