Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancers. In this study, we examined the therapeutic potential of selinexor...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Garg, Manoj, Kanojia, Deepika, Mayakonda, Anand, Ganesan, Trivadi S, Sadhanandhan, Bindhya, Suresh, Sidhanth, S., Sneha, Nagare, Rohit P., Said, Jonathan W., Doan, Ngan B., Ding, Ling-Wen, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Koeffler, H. Phillip
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575339/
https://ncbi.nlm.nih.gov/pubmed/28852098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10325-x
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