KPT-330 has antitumour activity against non-small cell lung cancer

BACKGROUND: We investigated the biologic and pharmacologic activities of a chromosome region maintenance 1 (CRM1) inhibitor against human non-small cell lung cancer (NSCLC) cells both in vitro and in vivo. METHODS: The in vitro and in vivo effects of a novel CRM1 inhibitor (KPT-330) for a large numb...

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Bibliographic Details
Main Authors:	Sun, H, Hattori, N, Chien, W, Sun, Q, Sudo, M, E-Ling, G L, Ding, L, Lim, S L, Shacham, S, Kauffman, M, Nakamaki, T, Koeffler, H P
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2014
Subjects:	Translational Therapeutics
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4102938/ https://ncbi.nlm.nih.gov/pubmed/24946002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.260
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KPT-330 has antitumour activity against non-small cell lung cancer

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