Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma

Exportin-1 mediates nuclear export of multiple tumor suppressor and growth regulatory proteins. Aberrant expression of exportin-1 is noted in human malignancies, resulting in cytoplasmic mislocalization of its target proteins. We investigated the efficacy of selinexor against liposarcoma cells both...

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Pubblicato in:Oncotarget
Autori principali: Garg, Manoj, Kanojia, Deepika, Mayakonda, Anand, Said, Jonathan W, Doan, Ngan B, Chien, Wenwen, Ganesan, Trivadi S, Huey, Linda Shyue Chuang, Venkatachalam, Nachiyappan, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Koeffler, H. Phillip
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352339/
https://ncbi.nlm.nih.gov/pubmed/27893412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13485
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