Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer

BACKGROUND: Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the antitumor effects of selinexor in vitro and in vivo. METHODS: Twenty-six breast...

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Détails bibliographiques
Publié dans:Breast Cancer Res
Auteurs principaux: Arango, Natalia Paez, Yuca, Erkan, Zhao, Ming, Evans, Kurt W., Scott, Stephen, Kim, Charissa, Gonzalez-Angulo, Ana Maria, Janku, Filip, Ueno, Naoto T., Tripathy, Debu, Akcakanat, Argun, Naing, Aung, Meric-Bernstam, Funda
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557476/
https://ncbi.nlm.nih.gov/pubmed/28810913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-017-0878-6
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