Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss

Background: PTEN-deficient tumors are dependent on PI3Kβ activity, making PI3Kβ a compelling target. We evaluated the efficacy of PI3Kβ inhibitor AZD8186 on tumors with PTEN loss. Results: In vitro cell viability assay and immunoblotting demonstrated that PTEN loss was significantly correlated with...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Owusu-Brackett, Nicci, Zhao, Ming, Akcakanat, Argun, Evans, Kurt W., Yuca, Erkan, Dumbrava, Ecaterina Ileana, Janku, Filip, Meric-Bernstam, Funda
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082117/
https://ncbi.nlm.nih.gov/pubmed/32215185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27503
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