KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

BACKGROUND AND AIMS: Increased expression of Chromosome Region Maintenance (CRM-1)/exportin-1 (XPO-1) has been correlated with poor prognosis in several aggressive tumors, making it an interesting therapeutic target. Selective Inhibitor of Nuclear Export (SINE) compounds bind to XPO-1 and block its...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Gravina, Giovanni Luca, Mancini, Andrea, Sanita, Patrizia, Vitale, Flora, Marampon, Francesco, Ventura, Luca, Landesman, Yosef, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Festuccia, Claudio
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666032/
https://ncbi.nlm.nih.gov/pubmed/26620414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1936-z
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