XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)

BACKGROUND: Exportin 1 (XPO1), also called chromosome region maintenance 1 (CRM1), is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus. AIM AND METHODS: To verify the hypothesis that XPO1 inhibition affects prostate cancer (PCa) metastatic potential...

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Bibliografische gegevens
Gepubliceerd in:J Hematol Oncol
Hoofdauteurs: Gravina, Giovanni Luca, Tortoreto, Monica, Mancini, Andrea, Addis, Alessandro, Di Cesare, Ernesto, Lenzi, Andrea, Landesman, Yosef, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Zaffaroni, Nadia, Festuccia, Claudio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283114/
https://ncbi.nlm.nih.gov/pubmed/25284315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-46
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