Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models

Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism. Inhibition of the transcriptional activity of HI...

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Udgivet i:Mar Drugs
Main Authors: Harris, Emily M., Strope, Jonathan D., Beedie, Shaunna L., Huang, Phoebe A., Goey, Andrew K. L., Cook, Kristina M., Schofield, Christopher J., Chau, Cindy H., Cadelis, Melissa M., Copp, Brent R., Gustafson, Kirk R., Figg, William D.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071056/
https://ncbi.nlm.nih.gov/pubmed/30029505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16070241
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