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Nitric Oxide Synthase and Structure-Based Inhibitor Design

Once it was discovered that the enzyme nitric oxide synthase (NOS) is responsible for the biosynthesis of NO, NOS became a drug target. Particularly important is the over production of NO by neuronal NOS (nNOS) in various neurodegenerative disorders. After the various NOS isoforms were identified, i...

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Bibliografiske detaljer
Udgivet i:Nitric Oxide
Main Authors: Poulos, Thomas L., Li, Huiying
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569579/
https://ncbi.nlm.nih.gov/pubmed/27890696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2016.11.004
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