Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase

Selective inhibitors of neuronal nitric oxide synthase (nNOS) have the potential to develop into new neurodegenerative therapeutics. Recently, we described the discovery of novel nNOS inhibitors (1a and 1b) based on a cis-pyrrolidine pharmacophore. These compounds and related ones were found to have...

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Detalhes bibliográficos
Main Authors: Xue, Fengtian, Huang, Jinwen, Ji, Haitao, Fang, Jianguo, Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925225/
https://ncbi.nlm.nih.gov/pubmed/20673724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.074
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