Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors

[Image: see text] Inhibition of bacterial nitric oxide synthase (bNOS) has the potential to improve the efficacy of antimicrobials used to treat infections by Gram-positive pathogens Staphylococcus aureus and Bacillus anthracis. However, inhibitor specificity toward bNOS over the mammalian NOS (mNOS...

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Udgivet i:J Med Chem
Main Authors: Holden, Jeffrey K., Kang, Soosung, Hollingsworth, Scott A., Li, Huiying, Lim, Nathan, Chen, Steven, Huang, He, Xue, Fengtian, Tang, Wei, Silverman, Richard B., Poulos, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306518/
https://ncbi.nlm.nih.gov/pubmed/25522110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501723p
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