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Electrostatic control of isoform selective inhibitor binding in nitric oxide synthase
Development of potent and isoform selective nitric oxide synthase (NOS) inhibitors is challenging owing to the structural similarity in the heme active sites. One amino acid difference between NOS isoforms, Asp597 in rat nNOS versus Asn368 in bovine eNOS, has been identified as the structural basis...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Biochemistry |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5287043/ https://ncbi.nlm.nih.gov/pubmed/27250740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00261 |
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