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The Role of Zinc in Isoform Selective Inhibitor Binding to Neuronal Nitric Oxide Synthase

In previous studies (Delker et al. (2010), J. Am. Chem. Soc. 132, 5437-5442) we determined the crystal structures of neuronal nitric oxide synthase (nNOS) complexed with nNOS-selective chiral pyrrolidine inhibitors, designed to have an aminopyridine group bound over the heme where it can electrostat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Delker, Silvia L., Xue, Fengtian, Li, Huiying, Jamal, Joumana, Silverman, Richard B., Poulos, Thomas L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193998/
https://ncbi.nlm.nih.gov/pubmed/21138269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1013479
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