The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases

[Image: see text] Many pyrrolidine-based inhibitors highly selective for neuronal nitric oxide synthase (nNOS) over endothelial NOS (eNOS) exhibit dramatically different binding modes. In some cases, the inhibitor binds in a 180° flipped orientation in nNOS relative to eNOS. From the several crystal...

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Detalhes bibliográficos
Main Authors: Li, Huiying, Jamal, Joumana, Delker, Silvia, Plaza, Carla, Ji, Haitao, Jing, Qing, Huang, He, Kang, Soosung, Silverman, Richard B., Poulos, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139154/
https://ncbi.nlm.nih.gov/pubmed/25089924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500561h
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