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The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases
[Image: see text] Many pyrrolidine-based inhibitors highly selective for neuronal nitric oxide synthase (nNOS) over endothelial NOS (eNOS) exhibit dramatically different binding modes. In some cases, the inhibitor binds in a 180° flipped orientation in nNOS relative to eNOS. From the several crystal...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American
Chemical Society
2014
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139154/ https://ncbi.nlm.nih.gov/pubmed/25089924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500561h |
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