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Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors

Nitric oxide (NO) is produced in Gram-positive pathogens Bacillus anthracis and Staphylococcus aureus by the bacterial isoform of nitric oxide synthase (NOS). Inhibition of bacterial nitric oxide synthase (bNOS) has been identified as a promising antibacterial strategy for targeting methicillin-resi...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Holden, Jeffrey K., Lewis, Matthew C., Cinelli, Maris A., Abdullatif, Ziad, Pensa, Anthony V., Silverman, Richard B., Poulos, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283056/
https://ncbi.nlm.nih.gov/pubmed/27607918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00786
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