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First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed several classes of 2-aminoquinoline-based nNOS inhibitors, but these compounds had drawbacks includin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Cinelli, Maris A., Reidl, Cory T., Li, Huiying, Chreifi, Georges, Poulos, Thomas L., Silverman, Richard B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429991/
https://ncbi.nlm.nih.gov/pubmed/32302123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01573
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