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First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed several classes of 2-aminoquinoline-based nNOS inhibitors, but these compounds had drawbacks includin...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Cinelli, Maris A., Reidl, Cory T., Li, Huiying, Chreifi, Georges, Poulos, Thomas L., Silverman, Richard B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429991/
https://ncbi.nlm.nih.gov/pubmed/32302123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01573
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