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Crystal Structures of Constitutive Nitric Oxide Synthases in Complex with De Novo Designed Inhibitors
New nitric oxide synthase (NOS) inhibitors were designed de novo with knowledge gathered from the studies on the nNOS-selective dipeptide inhibitors. Each of the new inhibitors consists of three fragments: an aminopyridine ring, a pyrrolidine, and a tail of various length and polarity. The in vitro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103786/ https://ncbi.nlm.nih.gov/pubmed/19296678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900007a |
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