Structure-guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase

Nitric oxide synthases (NOSs) comprise three closely related isoforms that catalyze the oxidation of l-arginine to l-citrulline and the important second messenger nitric oxide (NO). Pharmacological selective inhibition of neuronal NOS (nNOS) has the potential to be therapeutically beneficial in vari...

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Bibliographic Details
Main Authors: Huang, He, Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632207/
https://ncbi.nlm.nih.gov/pubmed/23451760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4000984
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