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Structure-guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase
Nitric oxide synthases (NOSs) comprise three closely related isoforms that catalyze the oxidation of l-arginine to l-citrulline and the important second messenger nitric oxide (NO). Pharmacological selective inhibition of neuronal NOS (nNOS) has the potential to be therapeutically beneficial in vari...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632207/ https://ncbi.nlm.nih.gov/pubmed/23451760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4000984 |
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