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Combination of Chiral Linkers with Thiophenecarboximidamide Heads to Improve the Selectivity of Inhibitors of Neuronal Nitric Oxide Synthase

To develop potent and selective nNOS inhibitors, a new series of double-headed molecules with chiral linkers that derive from natural amino acid derivatives have been designed and synthesized. The new structures integrate a thiophenecarboximidamide head with two types of chiral linkers, presenting e...

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Main Authors: Jing, Qing, Li, Huiying, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204799/
https://ncbi.nlm.nih.gov/pubmed/25149509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.079
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