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Chiral Linkers to Improve Selectivity of Double-Headed Neuronal Nitric Oxide Synthase Inhibitors

To develop potent and selective nNOS inhibitors, new double-headed molecules with chiral linkers that derive from natural amino acids or their derivatives have been designed. The new structures contain two ether bonds, which greatly simplifies the synthesis and accelerates structure optimization. In...

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Bibliografiske detaljer
Main Authors: Jing, Qing, Li, Huiying, Chreifi, Georges, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790268/
https://ncbi.nlm.nih.gov/pubmed/23993333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.034
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