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Chiral Linkers to Improve Selectivity of Double-Headed Neuronal Nitric Oxide Synthase Inhibitors

To develop potent and selective nNOS inhibitors, new double-headed molecules with chiral linkers that derive from natural amino acids or their derivatives have been designed. The new structures contain two ether bonds, which greatly simplifies the synthesis and accelerates structure optimization. In...

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Bibliografiska uppgifter
Huvudupphovsmän: Jing, Qing, Li, Huiying, Chreifi, Georges, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790268/
https://ncbi.nlm.nih.gov/pubmed/23993333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.034
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