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Chiral Linkers to Improve Selectivity of Double-Headed Neuronal Nitric Oxide Synthase Inhibitors

To develop potent and selective nNOS inhibitors, new double-headed molecules with chiral linkers that derive from natural amino acids or their derivatives have been designed. The new structures contain two ether bonds, which greatly simplifies the synthesis and accelerates structure optimization. In...

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書誌詳細
主要な著者: Jing, Qing, Li, Huiying, Chreifi, Georges, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790268/
https://ncbi.nlm.nih.gov/pubmed/23993333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.034
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