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Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

[Image: see text] Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic approach to target neurodegenerative disorders. However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability. We designed a nov...

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書目詳細資料
發表在:J Med Chem
Main Authors: Mukherjee, Paramita, Li, Huiying, Sevrioukova, Irina, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329833/
https://ncbi.nlm.nih.gov/pubmed/25489882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501719e
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