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Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
[Image: see text] Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic approach to target neurodegenerative disorders. However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability. We designed a nov...
Shranjeno v:
| izdano v: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American
Chemical
Society
2014
|
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329833/ https://ncbi.nlm.nih.gov/pubmed/25489882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501719e |
| Oznake: |
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