Nalaganje...

Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

[Image: see text] Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic approach to target neurodegenerative disorders. However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability. We designed a nov...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Mukherjee, Paramita, Li, Huiying, Sevrioukova, Irina, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329833/
https://ncbi.nlm.nih.gov/pubmed/25489882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501719e
Oznake: Označite
Brez oznak, prvi označite!