Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma

[Image: see text] Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy that combines the pharmacok...

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Bibliographic Details
Main Authors: Huang, He, Li, Huiying, Yang, Sun, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Meyskens, Frank L., Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983353/
https://ncbi.nlm.nih.gov/pubmed/24447275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401252e
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