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Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors

[Image: see text] The three important mammalian isozymes of nitric oxide synthase (NOS) are neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS). Inhibitors of nNOS show promise as treatments for neurodegenerative diseases. Eight easily synthesized compounds containing either one (2...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jing, Qing, Li, Huiying, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2013
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960082/
https://ncbi.nlm.nih.gov/pubmed/24660051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400381s
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