Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors

[Image: see text] The three important mammalian isozymes of nitric oxide synthase (NOS) are neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS). Inhibitors of nNOS show promise as treatments for neurodegenerative diseases. Eight easily synthesized compounds containing either one (2...

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Hlavní autoři: Jing, Qing, Li, Huiying, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960082/
https://ncbi.nlm.nih.gov/pubmed/24660051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400381s
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