DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity

The mutation rate of the mammalian mitochondrial genome is higher than that of the nuclear genome. Because mitochondrial and nuclear deoxyribonucleoside triphosphate (dNTP) pools are physically distinct and because dNTP concentrations influence replication fidelity, we asked whether mitochondrial dN...

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Autors principals: Song, Shiwei, Pursell, Zachary F., Copeland, William C., Longley, Matthew J., Kunkel, Thomas A., Mathews, Christopher K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC555996/
https://ncbi.nlm.nih.gov/pubmed/15784738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500253102
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