DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity

The mutation rate of the mammalian mitochondrial genome is higher than that of the nuclear genome. Because mitochondrial and nuclear deoxyribonucleoside triphosphate (dNTP) pools are physically distinct and because dNTP concentrations influence replication fidelity, we asked whether mitochondrial dN...

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Bibliografische gegevens
Hoofdauteurs: Song, Shiwei, Pursell, Zachary F., Copeland, William C., Longley, Matthew J., Kunkel, Thomas A., Mathews, Christopher K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC555996/
https://ncbi.nlm.nih.gov/pubmed/15784738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500253102
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