Chargement en cours...
Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity
Replication of the mitochondrial genome by DNA polymerase γ requires dNTP precursors that are subject to oxidation by reactive oxygen species generated by the mitochondrial respiratory chain. One such oxidation product is 8-oxo-dGTP, which can compete with dTTP for incorporation opposite template ad...
Enregistré dans:
| Auteurs principaux: | , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2008
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367704/ https://ncbi.nlm.nih.gov/pubmed/18276636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn062 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|