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Nucleoside Triphosphate Pool Asymmetry in Mammalian Mitochondria

Our laboratory has reported that deoxyribonucleoside triphosphate (dNTP) pools in rat tissue mitochondria are highly asymmetric, with dGTP predominating, and that the imbalance probably contributes toward the high spontaneous mutation rate of the mitochondrial genome. Ferraro et al. (Ferraro, P., Ni...

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Autori principali: Wheeler, Linda J., Mathews, Christopher K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089543/
https://ncbi.nlm.nih.gov/pubmed/21454602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236968
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