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POLE Proofreading Defects: Contributions to Mutagenesis and Cancer
DNA polymerases are uniquely poised to contribute to the elevated mutation burdens seen in many human tumors. These mutations can arise through a number of different polymerase-dependent mechanisms, including intrinsic errors made using template DNA and precursor dNTPs free from chemical modificatio...
Gorde:
| Argitaratua izan da: | DNA Repair (Amst) |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467506/ https://ncbi.nlm.nih.gov/pubmed/30818169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.02.007 |
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