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POLE proofreading mutation, immune response and prognosis in endometrial cancer

Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced imm...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: van Gool, Inge C., Bosse, Tjalling, Church, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839358/
https://ncbi.nlm.nih.gov/pubmed/27141333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1072675
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