POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

PURPOSE: Recent studies have shown that 7-12% of endometrial cancers (ECs) are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mutation burden, immune...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: van Gool, Inge C, Eggink, Florine A, Freeman-Mills, Luke, Stelloo, Ellen, Marchi, Emanuele, de Bruyn, Marco, Palles, Claire, Nout, Remi A, de Kroon, Cor D, Osse, Elisabeth M, Klenerman, Paul, Creutzberg, Carien L, Tomlinson, Ian PM, Smit, Vincent THBM, Nijman, Hans W, Bosse, Tjalling, Church, David N
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627582/
https://ncbi.nlm.nih.gov/pubmed/25878334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0057
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