Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition

High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and to explore immune profiles in other EC subgroups. We evaluated immune infiltration in 116 high-risk ECs...

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Vydáno v:Oncoimmunology
Hlavní autoři: Eggink, Florine A., Van Gool, Inge C., Leary, Alexandra, Pollock, Pamela M., Crosbie, Emma J., Mileshkin, Linda, Jordanova, Ekaterina S., Adam, Julien, Freeman-Mills, Luke, Church, David N., Creutzberg, Carien L., De Bruyn, Marco, Nijman, Hans W., Bosse, Tjalling
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353925/
https://ncbi.nlm.nih.gov/pubmed/28344870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1264565
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